A Primary Prevention Trial Using Nutritional Doses of Antioxidant Vitamins and Minerals in Cardiovascular Diseases and Cancers in a General Population
Identifieur interne : 004A99 ( Main/Exploration ); précédent : 004A98; suivant : 004B00A Primary Prevention Trial Using Nutritional Doses of Antioxidant Vitamins and Minerals in Cardiovascular Diseases and Cancers in a General Population
Auteurs : Serge Hercberg [France] ; Paul Preziosi [France] ; Serge Briançon [France] ; Pilar Galan [France] ; Isabelle Triol [France] ; Denis Malvy [France] ; Anne-Marie Roussel [France] ; Alain Favier [France]Source :
- Controlled Clinical Trials [ 0197-2456 ] ; 1998.
Descripteurs français
- KwdFr :
- Acide ascorbique (usage thérapeutique), Adulte, Adulte d'âge moyen, Association de médicaments, Bêtacarotène (usage thérapeutique), Femelle, France, Humains, Maladie coronarienne (), Mortalité, Mâle, Méthode en double aveugle, Sélénium (usage thérapeutique), Tumeurs (), Vitamine E (usage thérapeutique), Zinc (usage thérapeutique).
- MESH :
- usage thérapeutique : Acide ascorbique, Bêtacarotène, Sélénium, Vitamine E, Zinc.
- Adulte, Adulte d'âge moyen, Association de médicaments, Femelle, France, Humains, Maladie coronarienne, Mortalité, Mâle, Méthode en double aveugle, Tumeurs.
- Wicri :
- geographic : France.
English descriptors
- KwdEn :
- Adult, Ascorbic Acid (therapeutic use), Coronary Disease (prevention & control), Double-Blind Method, Drug Therapy, Combination, Female, France, Humans, Male, Middle Aged, Mortality, Neoplasms (prevention & control), Selenium (therapeutic use), Vitamin E (therapeutic use), Zinc (therapeutic use), beta Carotene (therapeutic use).
- MESH :
- chemical , therapeutic use : Ascorbic Acid, Selenium, Vitamin E, Zinc, beta Carotene.
- geographic : France.
- prevention & control : Coronary Disease, Neoplasms.
- Adult, Double-Blind Method, Drug Therapy, Combination, Female, Humans, Male, Middle Aged, Mortality.
Abstract
The SUpplementation en VItamines et Minéraux AntioXydants (SU.VI.MAX) Study is a randomized, double-blind, placebo-controlled, primary-prevention trial designed to test the efficacy of daily supplementation with antioxidant vitamins (vitamin C, 120 mg; vitamin E, 30 mg; and beta-carotene, 6 mg) and minerals (selenium, 100 μg; and zinc, 20 mg) at nutrition-level doses (one to three times the daily recommended dietary allowances) in reducing several major health problems in industrialized countries, especially the main causes of premature death, cancers and cardiovascular diseases. The present report describes the design, implementation, and baseline characteristics of participants in this 8-year cohort study, which started in 1994 in France; 12,735 eligible subjects (women aged 35–60, and men aged 45–60) were included in 1994 and will be followed for 8 years. Participants undergo a yearly visit consisting, every other year, of either biological sampling or clinical examination. They also regularly provide information on health events and dietary intake by filling out computerized questionnaires using the Minitel Telematic Network. Data on baseline characteristics of the participants suggest that the present sample is close to the national population in terms of geographic density, socioeconomic status, and the distribution of various major risk factors for the diseases under study. The choice of the study population should allow the results of this trial to apply to adult populations of both sexes in France and other industrialized countries.
Url:
DOI: 10.1016/S0197-2456(98)00015-4
Affiliations:
- France
- Auvergne-Rhône-Alpes, Grand Est, Lorraine (région), Rhône-Alpes, Île-de-France
- Grenoble, Nancy, Paris
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Le document en format XML
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(prevention & control)</term><term>Double-Blind Method</term><term>Drug Therapy, Combination</term><term>Female</term><term>France</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Mortality</term><term>Neoplasms (prevention & control)</term><term>Selenium (therapeutic use)</term><term>Vitamin E (therapeutic use)</term><term>Zinc (therapeutic use)</term><term>beta Carotene (therapeutic use)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acide ascorbique (usage thérapeutique)</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Association de médicaments</term><term>Bêtacarotène (usage thérapeutique)</term><term>Femelle</term><term>France</term><term>Humains</term><term>Maladie coronarienne ()</term><term>Mortalité</term><term>Mâle</term><term>Méthode en double aveugle</term><term>Sélénium (usage thérapeutique)</term><term>Tumeurs ()</term><term>Vitamine E (usage thérapeutique)</term><term>Zinc (usage thérapeutique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Ascorbic Acid</term><term>Selenium</term><term>Vitamin E</term><term>Zinc</term><term>beta Carotene</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>France</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Coronary Disease</term><term>Neoplasms</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Acide ascorbique</term><term>Bêtacarotène</term><term>Sélénium</term><term>Vitamine E</term><term>Zinc</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Double-Blind Method</term><term>Drug Therapy, Combination</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Mortality</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Association de médicaments</term><term>Femelle</term><term>France</term><term>Humains</term><term>Maladie coronarienne</term><term>Mortalité</term><term>Mâle</term><term>Méthode en double aveugle</term><term>Tumeurs</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>France</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The SUpplementation en VItamines et Minéraux AntioXydants (SU.VI.MAX) Study is a randomized, double-blind, placebo-controlled, primary-prevention trial designed to test the efficacy of daily supplementation with antioxidant vitamins (vitamin C, 120 mg; vitamin E, 30 mg; and beta-carotene, 6 mg) and minerals (selenium, 100 μg; and zinc, 20 mg) at nutrition-level doses (one to three times the daily recommended dietary allowances) in reducing several major health problems in industrialized countries, especially the main causes of premature death, cancers and cardiovascular diseases. The present report describes the design, implementation, and baseline characteristics of participants in this 8-year cohort study, which started in 1994 in France; 12,735 eligible subjects (women aged 35–60, and men aged 45–60) were included in 1994 and will be followed for 8 years. Participants undergo a yearly visit consisting, every other year, of either biological sampling or clinical examination. They also regularly provide information on health events and dietary intake by filling out computerized questionnaires using the Minitel Telematic Network. Data on baseline characteristics of the participants suggest that the present sample is close to the national population in terms of geographic density, socioeconomic status, and the distribution of various major risk factors for the diseases under study. The choice of the study population should allow the results of this trial to apply to adult populations of both sexes in France and other industrialized countries.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Grand Est</li><li>Lorraine (région)</li><li>Rhône-Alpes</li><li>Île-de-France</li></region><settlement><li>Grenoble</li><li>Nancy</li><li>Paris</li></settlement></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Hercberg, Serge" sort="Hercberg, Serge" uniqKey="Hercberg S" first="Serge" last="Hercberg">Serge Hercberg</name></region><name sortKey="Briancon, Serge" sort="Briancon, Serge" uniqKey="Briancon S" first="Serge" last="Briançon">Serge Briançon</name><name sortKey="Favier, Alain" sort="Favier, Alain" uniqKey="Favier A" first="Alain" last="Favier">Alain Favier</name><name sortKey="Galan, Pilar" sort="Galan, Pilar" uniqKey="Galan P" first="Pilar" last="Galan">Pilar Galan</name><name sortKey="Malvy, Denis" sort="Malvy, Denis" uniqKey="Malvy D" first="Denis" last="Malvy">Denis Malvy</name><name sortKey="Preziosi, Paul" sort="Preziosi, Paul" uniqKey="Preziosi P" first="Paul" last="Preziosi">Paul Preziosi</name><name sortKey="Roussel, Anne Marie" sort="Roussel, Anne Marie" uniqKey="Roussel A" first="Anne-Marie" last="Roussel">Anne-Marie Roussel</name><name sortKey="Triol, Isabelle" sort="Triol, Isabelle" uniqKey="Triol I" first="Isabelle" last="Triol">Isabelle Triol</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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